Effect of green tea leaves (Camellia sinensis) and carom seeds (trachyspermum ammi) extracts on male mice exposed to diazinon

Abstract

Objective: The present communication is based on herb, namely, Trachyspermum ammi L. belonging to family Apiaceae, commonly known as “Ajowan” or carom seeds, and green tea (Camellia sinensis, Theaceae) for the prevention of intoxication induced with a sublethal dose of diazinon. Methods: Male mice weighing around 6.5 mg/kg body weight were exposed to diazinon, a common pesticide used in plant cultivation. Carom seed and green tea leave extracts were given thereafter to the male mice to check their effect on the toxicity of diazinon. Results: After several weeks of exposure to these herbal extracts, there was a significant change observed in the hematobiochemical parameters with a significant increase in values of serum alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, creatine kinase, creatinine, glucose, and cholesterol. In contrast, no significant statistical difference was perceived in the values of all hematobiochemical parameters in mice treated with tea leaves extract, carom seed extract, and tea leave and carom seed extracts except the value of serum cholesterol in mice treated with carum seed extract which decreased as compared to the control group. Conclusion: These findings suggest the importance of the carom seeds and green tea and their combinatorial usage against diazinon toxicity, thus promising these plant products to be promising therapeutic agents against hepatotoxicity, cardiotoxicity, nephrotoxicity, and metabolic disorders due to diazinon toxicity. This also makes the safety of herbal products an important public health issue.