Targeting mutant p53 shows promise for sunscreens and skin cancer

12Citations
Citations of this article
20Readers
Mendeley users who have this article in their library.

Abstract

Chronic exposure to UV light is a risk factor for skin cancer in which signature mutations in the p53 tumor suppressor gene occur due to DNA damage and contribute to cancer development. In this issue of the JCI, Tang et al. report on their study of a nonimmunodeficient mouse model of UVBinduced skin cancer and human skin carcinoma cells and show that the mutant p53 conformation-modifying drug CP-31398 not only treats these tumors but also prevents them (see the related article beginning on page 3753). These studies have important implications for chemoprevention as well as therapy of common, mutant p53-driven tumors.

Cite

CITATION STYLE

APA

El-Deiry, W. S. (2007, December). Targeting mutant p53 shows promise for sunscreens and skin cancer. Journal of Clinical Investigation. https://doi.org/10.1172/JCI34251

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free