Modelling of transgenic mosquitoes and impact on malaria transmission

Abstract

Transgenic mosquitoes that are resistant tomalaria infection become one of the effective weaponsto control malaria transmission. To investigate the impact of releasing transgenic mosquitoes on the malaria transmission, we first formulate mathematical models for interactive wild and transgenic mosquitoes based on systems of differential equations.We consider both dominant and recessive transgenes and include density-dependent vital rates in the mosquitoes population and provide fundamental analysis for the dynamics of the interactive mosquitoes. Using a simple compartmental SEIR (susceptible-exposed-infective-recovered) malaria transmission model as our baseline model, we then introduce transgenic mosquitoes into the baseline model. We study the dynamics of the simple baseline model and the models with the transgenic mosquitoes. Based on the reproductive numbers and endemic equilibria for these models, we investigate the impact of releasing transgenic mosquitoes on malaria transmission. © 2011 Taylor & Francis.