Stem cell transplantation for primary immunodeficiency disease: Experience of a singapore hospital

Abstract

We retrospectively analyzed the outcomes of hematopoietic stem cell transplantation in 7 patients with primary immunodeficiency diseases treated at the National University Hospital, Singapore, over the period from December 1996 to January 2010. The primary immunodeficiency diseases managed were X-linked hyperimmunoglobulin M syndrome (n 1/4 3), severe combined immunodeficiency (n 1/4 1), leukocyte adhesion deficiency type 1 (n 1/4 1), chronic granulomatous disease (n 1/4 1), and Wiskott- Aldrich syndrome (n 1/4 1). The age of the patients ranged from 5 months to 17 years. Conditioning regimen depended on the type of immunodeficiency, whereas supportive treatment was tailored for differing pretransplant conditions. Eight stem cell transplantations were performed for 7 patients. Donors were HLA-matched sibling donors for 2 patients and unrelated donors for the rest. At the median follow-up of 8.6 years (range 2.2-15.0 years) as of December 2011, 6 patients were alive and cured of their primary diseases. Copyright © 2012 by World Allergy Organization.