CD4+ T cell responses in patients with chronic hepatitis C undergoing peginterferon/ribavirin therapy correlate with faster, but not sustained, viral clearance

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Abstract

T cell immune responses may be important for the elimination of chronic hepatitis C virus (HCV) infection during antiviral treatment. In the present study, the kinetics of T cell responses to HCV antigens (NS3-4 and core) were prospectively assessed and were correlated with virologic outcome in 31 patients with chronic HCV infection undergoing peginterferon-α2a/ribavirin therapy. NS3-4-directed T helper cell type 1 (Th1) responses were detected in 77% of patients with a significant decline in viremia at treatment week 4 but were not detected not in those with a slower viral decline. The detectability of NS3-4-directed Th1 responses was associated with faster viremia clearance, was short-lived, and did not seem to be associated with the final treatment outcome. © 2007 by the Infectious Diseases Society of America. All rights reserved.

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Aberle, J. H., Perstinger, G., Weseslindtner, L., Sinzinger, U., Gurguta, C., Steindl-Munda, P., … Holzmann, H. (2007). CD4+ T cell responses in patients with chronic hepatitis C undergoing peginterferon/ribavirin therapy correlate with faster, but not sustained, viral clearance. Journal of Infectious Diseases, 195(9), 1315–1319. https://doi.org/10.1086/513278

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