It is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally from the mother. Administration of magnesium sulfate was effective to abolish TdP. Conclusion: When mothers take tricyclic antidepressants during pregnancy, their newborns should be watched carefully for drug-induced long QT syndrome and TdP.What is Known:•Tricyclic antidepressant can prolong the QT interval. It may be used for depression in pregnancy.What is New:•This is the first neonatal case report of prolonged QT interval and TdP caused by clomipramine transferred transplacentally from the mother.
CITATION STYLE
Fukushima, N., Nanao, K., Fukushima, H., Namera, A., & Miura, M. (2016). A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants. European Journal of Pediatrics, 175(8), 1129–1132. https://doi.org/10.1007/s00431-016-2722-x
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