Microfluidics for Gamete Manipulation and Embryo Culture

Abstract

Microfluidics is an emerging field that holds immense potential for scientific discovery. By utilizing microfluidics, knowledge can be obtained in basic gamete/embryo developmental biology as well as expand our understanding in specialized areas, such as assisted reproduction. This review describes the technology of microfluidics and discusses applications for assisted reproduction technology. Development of an integrated microfluidic platform for assisted reproduction, which can manipulate gametes, embryos, their culture environment, and incorporate biomarker analysis, could have a dramatic impact on basic understanding of embryo physiology as well as provide significant improvements in current assisted reproductive technologies focused on treating infertility and preserving fertility.