This work describes the conditions for selective extraction of the alkaloids in Andreadoxa flava (Kallunki). The experiments were performed in a pilot plant SFE 500, in the following conditions. Extractor pressures 206.8 × 105, 241.3 × 105, 275.8 × 105 and 310.3 × 105 Pascal and pressures of 137.9 × 105, 69.0 × 10 5 and 55.2 × 105 Pascal for separators 6, 7 and 8 respectively. The temperatures were 40°C in the extractor and 20°C in the separators. The samples, extracted from A. flava leaves, were analysed by 1H NMR and GC/FID as well as by comparison with standards. This procedure allowed the identification for the first time of the 2-quinolone alkaloid 8-methoxy-N-methyl-flindersine in A. flava leaves of the. In addition, zanthophylline, 5-methoxyalmene and 8-methoxyflindersine were identified as the main alkaloids in leaves. Under the best conditions for zanthophylline extraction it was possible to obtain a purity of 79.4% while with other phytochemical technique 55.5% was obtained.
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Santana, L. L. B., Cardoso, L. A., Druzian, J. I., Souza, V. F., Costa, T. A. C., Nóbrega, D. A., … Velozo, E. S. (2006). Selectivity in the extraction of 2-quinolone alkaloids with supercritical CO2. Brazilian Journal of Chemical Engineering, 23(4), 525–530. https://doi.org/10.1590/S0104-66322006000400010
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