Influence of the chromatin density on the number of direct clustered damages calculated for proton and alpha irradiations using a Monte Carlo code

Abstract

The aim of this work is to evaluate the influence of the DNA density on the number of direct DNA clustered damages created by protons and alphas. Some simulations of the energy deposition were performed within two detailed DNA geometrical target models implemented in the Geant4 Monte Carlo code. An adapted DBSCAN algorithm was then used in order to determine the clustered damages.