Click synthesis and complexation properties of a new unsymmetrical macrocycle bearing 1,4-dioxabenzene and triazole units

Abstract

We report herein synthesis of a new triazole-based unsymmetrical macrocycle through Copper(I) catalyzed Alkyne - Azide Cycloadditon (CuAAC), using a copper(I)-N-heterocyclic carbene complex as catalyst. The obtained macrocycle was characterized by NMR spectroscopy and High Resolution Mass Spectrometry (HRMS). The complexation ability of the macrocycle towards various cations as well as its selectivity for a particular metal-ion was investigated by HRMS experiments.