Antibacterial activities of Some Mixed Isoniazid-Ibuprofen Metal Complexes: Chelation and Characterization

Abstract

The input of metallo-pharmaceutical to biomedical research is of high remarkable effect in drug design either as therapeutic, diagnostic or MRI imaging agents to mention few. Ranges of d - orbital transition metals: Cu(II), Zn(II), Mn(II), Ni(II), and Cd(II) complexes bearing Isoniazid-Ibuprofen mixed ligands have been synthesized. The prepared complexes were characterized by using microanalytical, infrared spectroscopy and CHN elemental analysis. FT-IR spectroscopic data showed that the ligands coordinate to the metal ion via the oxygen and nitrogen donor atoms from Isoniazid and oxygen of the carboxylic group and oxygen of the hydroxyl group of Ibuprofen. The elemental analysis measurement supports an octahedral geometry complexes proposed in line with the electronic structures of the metal ions. Comparative antibacterial study of the synthesized metal complexes and their parent ligands against Escherichia Coli, Staphylococcus aureus, and Pseudomonas aeruginosa microorganisms were carried out. [Ni(ISO)(IBR)Cl2] and [Co(ISO)(IBR)Cl2] exhibited the highest antibacterial activities than other complexes, however, the metal complex activities were found higher than the free ligands.