The role of p21 in regulating mammalian regeneration

21Citations
Citations of this article
76Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The MRL (Murphy Roths Large) mouse has provided a unique model of adult mammalian regeneration as multiple tissues show this important phenotype. Furthermore, the healing employs a blastema-like structure similar to that seen in amphibian regenerating tissue. Cells from the MRL mouse display DNA damage, cell cycle G2/M arrest, and a reduced level of p21 CIP1/WAF. A functional role for p21 was confirmed when tissue injury in an adult p21 -/- mouse showed a healing phenotype that matched the MRL mouse, with the replacement of tissues, including cartilage, and with hair follicle formation and a lack of scarring. Since the major canonical function of p21 is part of the p53/p21 axis, we explored the consequences of p53 deletion. A regenerative response was not seen in a p53 -/- mouse and the elimination of p53 from the MRL background had no negative effect on the regeneration of the MRL.p53 -/- mouse. An exploration of other knockout mice to identify p21-dependent, p53-independent regulatory pathways involved in the regenerative response revealed another significant finding showing that elimination of transforming growth factor-1 displayed a healing response as well. These results are discussed in terms of their effect on senescence and differentiation. © 2011 BioMed Central Ltd.

Cite

CITATION STYLE

APA

Arthur, L., & Heber-Katz, E. (2011). The role of p21 in regulating mammalian regeneration. Stem Cell Research and Therapy. https://doi.org/10.1186/scrt71

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free