Background: Heart failure contributes to the excess mortality experienced by patients with rheumatoid arthritis (RA) (1). Impaired diastolic function represents a pre-clinical cardiac alteration which is highly predictive of cardiac events and often progresses to heart failure. Diastolic dysfunction is the most common cause of heart failure in patients with a preserved ejection fraction. Whereas RA is associated with an increased prevalence of impaired diastolic function (2,3), the pathophysiological mechanisms that mediate this comorbidity await further elucidation. Objective(s): This study aimed to identify potential determinants of ventricular (LV) diastolic function in patients with RA. Method(s): LV diastolic function was determined in 176 patients with RA; 9 patients had established cardiovascular disease. LV diastolic function was determined by echocardiography from the ratio of early-to-late transmitral blood flow velocity (E/A), the ratio of E to the mean of the lateral and septal wall myocardial tissue lengthening at the mitral annulus (e') (E/e'), and the lateral e'. Relationships of comprehensively evaluated traditional cardiovascular risk factors and RA characteristics with markers of LV diastolic function were determined in confounder adjusted multivariate regression models. Result(s): Disease duration (partial r=-0.23, p=0.00), rheumatoid factor status (partial r=-0.16, p=0.04) and erythrocyte sedimentation rate (partial r=-0.16, p=0.04) were associated with lower logarithmically transformed (log) E/A. Upon further adjustment for left ventricular mass index or relative wall thickness, these relationships remained significant (p
CITATION STYLE
Millen, A., Mokotedi, L., Gunter, S., Robinson, C., Norton, G., Woodiwiss, A., … Dessein, P. (2017). THU0117 Independent associations of disease characteristics and cardiovascular risk factors with left ventricular diastolic function in rheumatoid arthritis (pp. 245.2-245). BMJ. https://doi.org/10.1136/annrheumdis-2017-eular.4205
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