Spatio-temporal characterization of axoplasmic fluid pressure with respect to ionic diffusivities

Abstract

In this paper, spatio-temporal characterization of axoplasmic fluid pressure has been performed with respect to ionic diffusivities. It has been observed that the propagation speed of axoplasmic fluid pressure is 19.5 m/s when longitudinal ionic diffusivities are considered along with ionic conductances at a temperature of 18.5∘C. However, this propagation speed of axoplasmic fluid pressure increases to 19.7 m/s when longitudinal ionic diffusivities are considered along with temperature-dependent diffusivities across the membrane at the same temperature of 18.5∘C. This is an important result where it has been possible to obtain axoplasmic pressure propagation velocities with respect to temperature-dependent ionic diffusivities. Also, based on the fact that increased intracellular pressure may lead to a number of neuronal disorders, temperature-dependent ionic diffusivities can be further fine-tuned to reduce the intracellular pressure and hence avoiding neuronal disorders.