The blood-brain barrier is a unique cell-based restrictive barrier that prevents the entry of many substances, including most therapeutics, into the central nervous system. A wide range of nanoparticulate delivery systems have been investigated with the aim of targeting therapeutics (drugs, nucleic acids, proteins) to the brain following administration by various routes. This review provides a comprehensive description of the design and formulation of these nanoparticles including the rationale behind individual approaches. In addition, the ability of currently available in-vitro BBB models to accurately predict the in-vivo performance of targeted nanoparticles is critically assessed.
Mc Carthy, D. J., Malhotra, M., O’Mahony, A. M., Cryan, J. F., & O’Driscoll, C. M. (2015). Nanoparticles and the blood-brain barrier: Advancing from in-vitro models towards therapeutic significance. Pharmaceutical Research, 32(4), 1161–1185. https://doi.org/10.1007/s11095-014-1545-6
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