Dorsal pancreas agenesis in N-cadherin-deficient mice

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Abstract

Members of the cadherin family of cell adhesion molecules are thought to be crucial regulators of tissue patterning and organogenesis. During pancreatic ontogeny N-cadherin is initially expressed in the pancreatic mesenchyme and later in pancreatic endoderm. Analysis of N-cadherin-deficient mice revealed that these mice suffer from selective agenesis of the dorsal pancreas. Further analysis demonstrated that the mechanism for the lack of a dorsal pancreas involves an essential function of N-cadherin as a survival factor in the dorsal pancreatic mesenchyme. © 2001 Academic Press.

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Esni, F., Johansson, B. R., Radice, G. L., & Semb, H. (2001). Dorsal pancreas agenesis in N-cadherin-deficient mice. Developmental Biology, 238(1), 202–212. https://doi.org/10.1006/dbio.2001.0405

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