Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain

163Citations
Citations of this article
218Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

In the brain, a paravascular space exists between vascular cells and astroglial end-foot processes, creating a continuous sheath surrounding blood vessels. Using in vivo two-photon imaging we demonstrate that the paravascular circulation facilitates selective transport of small lipophilic molecules, rapid interstitial fluid movement and widespread glial calcium signaling. Depressurizing the paravascular system leads to unselective lipid diffusion, intracellular lipid accumulation and pathological signaling in astrocytes. As the central nervous system is devoid of lymphatic vessels, the paravascular space may serve as a lymphatic equivalent that represents a separate highway for the transport of lipids and signaling molecules.

Cite

CITATION STYLE

APA

Thrane, V. R., Thrane, A. S., Plog, B. A., Thiyagarajan, M., Iliff, J. J., Deane, R., … Nedergaard, M. (2013). Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain. Scientific Reports, 3. https://doi.org/10.1038/srep02582

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free