Biocompatibility and antibacterial activity studies of gellan gum and alginate thin film encapsulating curcumin as a wound skin care dressing

Abstract

The quest for biocompatible and antibacterial wound skin care dressings based on biopolymers has become a burgeoning focus in biomedicine. A wound care dressing of GG+SA@CUR thin film was prepared, and its properties were evaluated. FTIR analysis revealed distinct functional groups for GG, SA, and CUR. The GG+SA@CUR thin film is in an amorphous state, showing that CUR was successfully encapsulated for controlled drug release. The SEM images show the presence of CUR particles, which cause the film to have significant antibacterial properties. The inhibition zone was found to be 16.67 ± 0.26 mm and 12.06 ± 0.08 mm against S. aureus and E. coli. The good biocompatibility characteristics of the GG+SA@CUR thin film were proven by the high number of fibroblast cells. The scratch cells migrated faster after being treated with GG+SA@CUR film and accelerated wound healing in in vitro conditions, indicating their potential as new transdermal skin wound care.