Mechanosynthesis of Eutectics of Anti-Inflammatory Drug Ethenzamide – A Comparison with Analogous Cocrystals

Abstract

Mechanochemical milling of ethenzamide (ETZ), a nonsteroidal anti-inflammatory drug, with substituted aromatic carboxylic acids as well as anti-tuberculosis drug pyrazinamide (PZA) resulted in the formation of eutectics. Although a large number of cocrystals as well as polymorphic cocrystals are reported for ETZ, for the first time we have synthesized six eutectics including an instance of a drug-drug eutectic system. Supramolecular synthon energy calculations validate the formation of eutectic mixtures over cocrystals with coformers considered in our study.