Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020

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Abstract

Two London care homes experienced a second COVID- 19 outbreak, with 29/209 (13.9%) SARS-CoV-2 RT-PCRpositive cases (16/103 residents, 13/106 staff). In those with prior SARS-CoV-2 exposure, 1/88 (1.1%) individuals (antibody positive: 87; RT-PCR-positive: 1) became PCR-positive compared with 22/73 (30.1%) with confirmed seronegative status. After four months protection offered by prior infection against re-infection was 96.2% (95% confidence interval (CI): 72.7-99.5%) using risk ratios from comparison of proportions and 96.1% (95% CI: 78.8-99.3%) using a penalised logistic regression model.

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Jeffery-Smith, A., Iyanger, N., Williams, S. V., Chow, J. Y., Aiano, F., Hoschler, K., … Zambon, M. (2021). Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020. Eurosurveillance, 26(5). https://doi.org/10.2807/1560-7917.ES.2021.26.5.2100092

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