POS0013 MUSCULOSKELETAL MANIFESTATIONS IN PATIENTS WITH ENDOCRINE DISEASES IN TERTIARY SERVICE

Abstract

Background: Musculoskeletal diseases represent about 50 to 70% of the frequency of chronic diseases according to previous studies (SOUZA, OLIVEIRA, 2015). Chronic pain is often associated with these diseases and is an important cause of care in the health service. Thus, medical professionals are required to adequately manage their patients. Despite the lack of knowledge of some, endocrine diseases are basic diseases linked to musculoskeletal manifestations. Thus, secondary arthropathies of the non-rheumatologic origin or osteoarticular complaints that simulate or show rheumatic diseases can be seen in patients with endocrine diseases during their evolution or in the initial phase along with other systemic symptoms. Based on this concept, the musculoskeletal manifestations presented by patients with endocrine disorders in tertiary health service were monitored and evaluated. Objectives: The objective of this study is to characterize the musculoskeletal manifestations in patients with endocrine diseases: type 1 and type 2 diabetes mellitus; hypothyroidism; hyperthyroidism and pituitary diseases and to clinically classify the patients based on physical and imaging findings. Methods: A cross-sectional and descriptive study, where clinical screening was performed at the endocrinology outpatient clinic, in which patients with musculoskeletal complaints were identified. These patients were referred for evaluation with a rheumatologist with clinical, laboratory and imaging investigation for the diagnosis of rheumatic disease. A questionnaire with epidemiological and clinical data was applied. Results: In this study, 325 patients with endocrine diseases were interviewed, 53 ± 16.4 years old, 258 (80%) were female and 64 (20%) males. Of the interviewed patients, 236 (72.8%) reported musculoskeletal pain, being that 196 (75.9%) of the women and 33% of the men indicated this type of symptom. Regarding endocrine diseases, the most frequent was Diabetes Mellitus type 2 with 158 patients (48.6%), and 75% of these people have chronic musculoskeletal pain, most 5 to 7 times a week, showing an intrinsic character of this disease with pain complaints from a large part of this population. It was also identified the prevalence of 25% of Hypothyroidism, 12% of Diabetes type 1, 9% of Hyperthyroidism and less expressive amounts of other endocrine diseases such as Acromegaly (2.1%), Gigantism (0.3%) and similar. About 63% of those who have pain are not followed up in the service of rheumatology, 42% of these have already indicated these pains to their endocrinologist, however they have not had their complaint properly flagged. Of these patients, 94 (29%) use Antihypertensives and 25% Oral Antidiabetics. The most notable diagnoses in rheumatology are: Rheumatoid Arthritis (29%); Osteoarthritis (27%); Osteoporosis and Fibromyalgia both with 20.6% of diagnoses and Psoriatic Arthritis and GOUT with 6%. The main regions that are subject to pain are the Hands (52%); Knees (40%); Spine and feet with 30% each. Conclusion: Although there is a demand of more confirmatory studies, our preliminary results showed the mutuality between endocrine diseases and musculoskeletal manifestations and, therefore, that rheumatological findings are increasingly frequent in this population. The high prevalence of these symptoms secondary to endocrine diseases raises serious questions in order to improve the quality of life of these patients, and also to increase the number of researches in this field, because the pathophysiological mechanisms of this association are not well elucidated and, from this, expand this information to professionals who may not be aware of this relationship.