Schizophrenia genomics and proteomics: Are we any closer to biomarker discovery?

28Citations
Citations of this article
80Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The field of proteomics has made leaps and bounds in the last 10 years particularly in the fields of oncology and cardiovascular medicine. In comparison, neuroproteomics is still playing catch up mainly due to the relative complexity of neurological disorders. Schizophrenia is one such disorder, believed to be the results of multiple factors both genetic and environmental. Affecting over 2 million people in the US alone, it has become a major clinical and public health concern worldwide. This paper gives an update of schizophrenia biomarker research as reviewed by Lakhan in 2006 and gives us a rundown of the progress made during the last two years. Several studies demonstrate the potential of cerebrospinal fluid as a source of neuro-specific biomarkers. Genetic association studies are making headway in identifying candidate genes for schizophrenia. In addition, metabonomics, bioinformatics, and neuroimaging techniques are aiming to complete the picture by filling in knowledge gaps. International cooperation in the form of genomics and protein databases and brain banks is facilitating research efforts. While none of the recent developments described here in qualifies as biomarker discovery, many are likely to be stepping stones towards that goal. © 2009 Lakhan and Kramer; licensee BioMed Central Ltd.

References Powered by Scopus

The endophenotype concept in psychiatry: Etymology and strategic intentions

4645Citations
N/AReaders
Get full text

Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins

932Citations
N/AReaders
Get full text

Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: The SzGene database

913Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells

204Citations
N/AReaders
Get full text

New Measures of Mental State and Behavior Based on Data Collected From Sensors, Smartphones, and the Internet

92Citations
N/AReaders
Get full text

Aberrant microRNA expression in peripheral plasma and mononuclear cells as specific blood-based biomarkers in schizophrenia patients

88Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Lakhan, S. E., & Kramer, A. (2009, January 7). Schizophrenia genomics and proteomics: Are we any closer to biomarker discovery? Behavioral and Brain Functions. https://doi.org/10.1186/1744-9081-5-2

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 34

59%

Researcher 20

34%

Lecturer / Post doc 3

5%

Professor / Associate Prof. 1

2%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 24

43%

Medicine and Dentistry 15

27%

Neuroscience 11

20%

Psychology 6

11%

Save time finding and organizing research with Mendeley

Sign up for free