Reconstruction of skin defects is often a challenging effort due to the currently limited reconstructive options. In this sense, tissue engineering has emerged as a possible alternative to replace or repair diseased or damaged tissues from the patient’s own cells. A substantial number of tissue-engineered skin substitutes (TESSs) have been conceived and evaluated in vitro and in vivo showing promising results in the preclinical stage. However, only a few constructs have been used in the clinic. The lack of standardization in evaluation methods employed may in part be responsible for this discrepancy. This review covers the most well-known and up-to-date methods for evaluating the optimization of new TESSs and orientative guidelines for the evaluation of TESSs are pro-posed.
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CITATION STYLE
Linares-Gonzalez, L., Rodenas-Herranz, T., Campos, F., Ruiz-Villaverde, R., & Carriel, V. (2021, October 1). Basic quality controls used in skin tissue engineering. Life. MDPI. https://doi.org/10.3390/life11101033