Peptidomimetic building blocks for drug discovery: An overview

Abstract

We have developed new asymmetric and enantioselective routes for the preparation of a variety of conformationally constrained peptidomimetic building blocks. These molecules include α-methylcysteinc, α-methylthreonine, allo-threonine, α,β-dimethylcysteine, α,β-dimethyltryptophan, twisted amide, and substituted lanthionine structures. It has been shown that these molecules are very useful building blocks for the peptidomimetic drug design. © 1996, Walter de Gruyter GmbH, Berlin/Boston. All rights reserved.