Preemption of human cell mediated lympholysis by a suppressive mechanism activated in mixed lymphocyte cultures

Abstract

The regulation of B cell and T cell immune responses has been extensively examined and in the experimental animal appears to involve regulatory or 'suppressor' T cells. The limitations of in vitro experimentation have made comparable study of nonpathological human suppression quite difficult. The authors report an in vitro method that generates and quantitates suppressor activity in man after antigen specific activation in mixed leukocyte culture (MLC).