A series of 2-hydroxy-3-arylnaphthalene-1,4-diones (3-aryllawsones) were synthesized by Suzuki-Miyaura cross coupling reaction of 3-iodolawsone with arylboronic acids/esters. The hydroxylated resulting products were transformed into their corresponding N,N-diethyl carbamates. The antineoplastic and antileishmanial activities of the compounds were evaluated and compared with lapachol and its carbamate, providing promising results.
CITATION STYLE
Gomes, S. L. S., Militão, G. C. G., Costa, A. M., Pessoa, C., Costa-Lotufo, L. V., Cunha, E. F., … Da Silva, A. J. M. (2017). Suzuki-Miyaura coupling between 3-iodolawsone and arylboronic acids. Synthesis of lapachol analogues with antineoplastic and antileishmanial activities. Journal of the Brazilian Chemical Society, 28(8), 1573–1584. https://doi.org/10.21577/0103-5053.20160326
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