Effect of acetazolamide for long-lasting paroxysmal dystonia in a patient with multiple sclerosis: A case report and review of literature

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Abstract

Dystonia is a rare manifestation of multiple sclerosis (MS), but it always interferes with the functional performance and quality of life. We report a rare case of long-lasting paroxysmal dystonia associated with MS. The patient was a 40-year-old woman with relapsing- remitting MS for 6 years. During the latest attack of MS, she suffered from long-lasting paroxysmal dystonia in her left hand. Despite treatment with pulse high-dose intravenous methylprednisolone, interferon, and baclofen, along with occupational therapy, the dystonia persisted and significantly bothered her daily activities. Finally, she was treated with oral acetazolamide (250 mg, three times a day for 4 days), which was very effective for the control of her dystonia. The dystonic movement subsided without recurrence in a follow-up of 17 months. We advocate this effective and safe treatment for patients with paroxysmal dystonia associated with MS. © 2013 Hsieh et al, publisher and licensee Dove Medical Press Ltd.

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Hsieh, P. C., Chen, S. M., Guo, Y. H., Kuan, T. S., Yen, W. J., Chang, W. C., & Lin, Y. C. (2013). Effect of acetazolamide for long-lasting paroxysmal dystonia in a patient with multiple sclerosis: A case report and review of literature. Neuropsychiatric Disease and Treatment, 9, 445–448. https://doi.org/10.2147/NDT.S43688

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