Comparative study of the effects of diosmin and diosmetin on fat accumulation, dyslipidemia, and glucose intolerance in mice fed a high-fat high-sucrose diet

12Citations
Citations of this article
18Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

This study compared the effects of diosmin and its aglycone, diosmetin, on body weight, liver fat, serum cholesterol, and glucose intolerance in male C57BL/6 mice fed a high-fat high-sucrose (HFHS) diet for 12 weeks. The mice were divided into four groups that received the following diets: normal diet (ND), HFHS diet, HFHS diet with 0.5% diosmin, and HFHS diet with 0.5% diosmetin. The body weight increased significantly in the HFHS diet group but decreased significantly in the HFHS diet with 0.5% diosmin group. The diosmin and diosmetin treatment inhibited fat accumulation in liver and epididymal tissues, and improved glucose intolerance by lowering glucose levels during a glucose tolerance test; these effects were greater in the diosmin group than those in the diosmetin group. Furthermore, only diosmin significantly ameliorated dyslipidemia, by reducing TC and LDL-C levels, while diosmetin had little effect on these parameters. Taken together, the results showed that diosmin and diosmetin can prevent fat accumulation and glucose intolerance; however, diosmin was more effective and also showed an antidyslipidemic effect.

References Powered by Scopus

Update on uses and properties of citrus flavonoids: New findings in anticancer, cardiovascular, and anti-inflammatory activity

1024Citations
N/AReaders
Get full text

Dietary flavonoid aglycones and their glycosides: Which show better biological significance?

530Citations
N/AReaders
Get full text

Flavonoid metabolism: The interaction of metabolites and gut microbiota

360Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Wound healing activity of 80% methanol leaf extract of Zehneria scabra (L.f) sond (Cucurbitaceae) in mice

23Citations
N/AReaders
Get full text

Diosmin, a citrus fruit-derived phlebotonic bioflavonoid protects rats from chronic kidney disease-induced loss of bone mass and strength without deteriorating the renal function

18Citations
N/AReaders
Get full text

Ethnopharmacological and phytochemical attributes of Indian Tinospora species: A comprehensive review

15Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Chung, S., Kim, H. J., Choi, H. K., Park, J. H., & Hwang, J. T. (2020). Comparative study of the effects of diosmin and diosmetin on fat accumulation, dyslipidemia, and glucose intolerance in mice fed a high-fat high-sucrose diet. Food Science and Nutrition, 8(11), 5976–5984. https://doi.org/10.1002/fsn3.1883

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 7

88%

Researcher 1

13%

Readers' Discipline

Tooltip

Medicine and Dentistry 4

40%

Pharmacology, Toxicology and Pharmaceut... 3

30%

Immunology and Microbiology 2

20%

Energy 1

10%

Save time finding and organizing research with Mendeley

Sign up for free