Novel approaches for the in-vitro diagnosis of type I allergies

Abstract

Diagnosis of type I allergic reactions are based on the combination of a patient’s history, skin testing and laboratory tests to detect specific IgE (sIgE). The methodology for measuring sIgE has evolved during recent years. Furthermore stimulation tests on the cellular level measure mediators such as histamine and leukotriens. Cellular stimulation tests and histamine measurement can be performed only in specialized laboratories, require fresh blood samples and are not applicable for routine diagnosis. The following chapter summarizes recent advances in the detection of sIgE.