Functional cell-based assays are useful for comparing the effect of a treatment, drug, or condition on cells in culture. Cell lines are a commonly used model to replicate a normal biological process or a pathological condition. Trophoblasts within the placenta are required to perform a variety of functions, which include proliferation, differentiation, migration, and invasion for efficient placentation to occur. These functions are impaired in trophoblasts from preeclamptic pregnancies, and therefore functional cell-based assays can be utilized to measure differences and dissect molecular regulatory pathways.
CITATION STYLE
Powell, K. L., & Ashton, A. W. (2018). Analyzing trophoblast function using cell-based assays. In Methods in Molecular Biology (Vol. 1710, pp. 233–246). Humana Press Inc. https://doi.org/10.1007/978-1-4939-7498-6_18
Mendeley helps you to discover research relevant for your work.