Acute and long-term complications of radiotherapy for Hodgkin lymphoma

Abstract

Radiation therapy for Hodgkin lymphoma (HL) has undergone major transformations over the last few decades and remains an important modality in the treatment of the disease. Some of the complications of radiation treatment described in the literature may not be entirely applicable to patients treated in the modern era. However, even as HL therapy evolves, it is imperative to continue the long-term follow-up of survivors with careful documentation of the types of late effects that may be associated with new treatments (both radiation therapy and chemotherapy). The contribution of other modifying factors, including genetic factors, environmental factors, and lifestyle choices may also have important implications for patient counseling and follow-up recommendations. An improved recognition and understanding of therapy-related complications can inform modifications in regimens to minimize exposures to cytotoxic agents. However, reduction of current treatments that have established efficacy should not be undertaken outside the context of clinical trials. Optimal treatments for HL will require careful balancing to continue to maximize efficacy while minimizing toxicity. © 2011 Springer-Verlag Berlin Heidelberg.