Azithromycin levels in cervical mucus and plasma after a single 1.0 g oral dose for chlamydial cervicitis

Abstract

Objective - To determine the kinetics of azithromycin in cervical mucus and plasma. Subjects and methods - Azithromycin concentrations were determined in plasma and mucus samples from 20 women with cervical chlamydial infection one, seven and fourteen days after a single oral 1.0 g dose. Results - In mucus, all measurable azithromycin concentrations were above the minimal inhibitory concentration against Chlamydia trachomatis on day 7 as well as on day 14. Conclusion - The high cervical mucus concentrations of azithromycin can explain the high clinical and microbiological efficacy.