A robust in vivo model for B cell precursor acute lymphoblastic leukemia

1Citations
Citations of this article
21Readers
Mendeley users who have this article in their library.

Abstract

B cell precursor acute lymphoblastic leukemia (BCP ALL) is the most common malignancy in children. While treatments have improved remarkably over the past four decades, resistant disease and late effects that result from cytotoxic chemotherapy remain serious problems for individuals with BCP ALL. Improved genetic tools have led to the discovery of numerous somatic mutations associated with BCP ALL, leading to a framework for the genetic classification of BCP ALL. In this issue of the JCI, Duque-Afonso et al. develop an accurate in vivo model for BCP ALL that recapitulates the key features of human disease, including acquired mutations in genes encoding PAX5 and components of the JAK/STAT pathway. The authors further show, as proof of principle, that this model can be used to evaluate the efficacy of drugs designed to target specific acquired mutations in patients with BCP ALL.

Cite

CITATION STYLE

APA

Fry, T. J., & Aplan, P. D. (2015, September 1). A robust in vivo model for B cell precursor acute lymphoblastic leukemia. Journal of Clinical Investigation. American Society for Clinical Investigation. https://doi.org/10.1172/JCI83799

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free