ACE insertion/deletion (I/D) polymorphism and diabetic nephropathy

  • Rahimi Z
N/ACitations
Citations of this article
30Readers
Mendeley users who have this article in their library.

Abstract

© 2014 by Journal of Nephropathology (JNP). Context: Angiotensin converting enzyme (ACE) gene encodes ACE, a key component of renin angiotensin system (RAS), plays an important role in blood pressure homeostasis by generating the vasoconstrictor peptide angiotensin II. Evidence Acquisitions: Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched. Results: The presence of ACE insertion/deletion (I/D) polymorphism affects the plasma level of ACE. ACE DD genotype is associated with the highest systemic and renal ACE levels compared with the lowest ACE activity in carriers of II genotype. Conclusions: In this review focus has been performed on the study of ACE I/D polymorphism in various populations and its influence on the risk of onset and progression of diabetic nephropathy. Also, association between ACE I/D polymorphism and response to ACE inhibitor and angiotensin II receptor antagonists will be reviewed. Further, synergistic effect of this polymorphism and variants of some genes on the risk of development of diabetic nephropathy will be discussed.

Cite

CITATION STYLE

APA

Rahimi, Z. (2012). ACE insertion/deletion (I/D) polymorphism and diabetic nephropathy. Journal of Nephropathology, 1(3), 143–151. https://doi.org/10.5812/nephropathol.8109

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free