Derivatives of the natural occurring and inexpensive terpene (R)-limonene were synthetized and completely characterized. Starting from internal olefin epoxidation, followed by epoxide opening with sodium azide and azide reduction with LiAlH4, two chiral amino-alcohols were obtained. The amino-alcohols were reacted with three different aldehydes, generating six new imino-alcohols, two of them yielding crystals suitable for X-ray diffraction characterization. The reduction of four of these compounds with LiAlH4 led to new amino-alcohols. All derivatives were obtained with good overall yields through simple reaction protocols.
CITATION STYLE
Fuscaldo, R. S., Boeira, E. O., Stieler, R., Lüdtke, D. S., & Gregório, J. R. (2020). Chiral amino and imino-alcohols based on (R)-limonene. Journal of the Brazilian Chemical Society, 31(3), 438–446. https://doi.org/10.21577/0103-5053.20190201
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