Euplotes crassus has genes encoding telomere-binding proteins and telomere-binding protein homologs

59Citations
Citations of this article
16Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

We have identified two 1.6 kb macronuclear DNA molecules from Euplotes crassus that hybridize to the α subunit of the Oxytricha telomere protein. We have shown that one of these molecules encodes the 51 kDa Euplotes telomere protein while the other appears to encode a homolog of the telomere protein. Although this homolog clearly differs in sequence from the Euplotes telomere protein, the two proteins share extensive amino acid sequence identity with each other and with the α subunit of the Oxytricha telomere protein. In all three proteins 35-36% of the amino acids are identical, while 54-56% are similar. The most extended regions of sequence conservation map within the N-terminal section; this section has been shown to comprise the DNA-binding domain in the Euplotes telomere protein. Our findings suggest that some of the conserved amino acids may be involved in DNA recognition and binding. The gene encoding the telomere protein homolog contains two introns; one of these introns is only 24 bp in length. This lathe smallest mRNA intron reported to date. © 1992 Oxford University Press.

Cite

CITATION STYLE

APA

Wang, W., Skopp, R., Scofield, M., & Price, C. (1992). Euplotes crassus has genes encoding telomere-binding proteins and telomere-binding protein homologs. Nucleic Acids Research, 20(24), 6621–6629. https://doi.org/10.1093/nar/20.24.6621

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free