Action of clathrodin and analogues on voltage-gated sodium channels

7Citations
Citations of this article
21Readers
Mendeley users who have this article in their library.

Abstract

Clathrodin is a marine alkaloid and believed to be a modulator of voltage-gated sodium (Na V ) channels. Since there is an urgent need for small molecule Na V channel ligands as novel therapeutics, clathrodin could represent an interesting lead compound. Therefore, clathrodin was reinvestigated for its potency and Na V channel subtype selectivity. Clathrodin and its synthetic analogues were subjected to screening on a broad range of Na V channel isoforms, both in voltage clamp and patch clamp conditions. Even though clathrodin was not found to exert any activity, some analogues were capable of modulating the Na V channels, hereby validating the pyrrole-2-aminoimidazole alkaloid structure as a core structure for future small molecule-based Na V channel modulators. © 2014 by the authors; licensee MDPI.

Cite

CITATION STYLE

APA

Peigneur, S., Žula, A., Zidar, N., Chan-Porter, F., Kirby, R., Madge, D., … Tytgat, J. (2014). Action of clathrodin and analogues on voltage-gated sodium channels. Marine Drugs, 12(4), 2132–2143. https://doi.org/10.3390/md12042132

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free