© 2017 The Authors. Background. A multicenter prospective observational study evaluated the effect of gastrointestinal cancer chemotherapy with short-term periodic steroid premedication on bone metabolism. Patients and Methods. Seventy-four patients undergoing chemotherapy for gastrointestinal cancer were studied. The primary endpoints were changes in bone mineral densities (BMDs) and metabolic bone turnover 16 weeks after initiation of chemotherapy. BMDs, measured by dual-energy x-ray absorptiometry, and serum cross-linked N-telopeptides of type I collagen (sNTX), and bone alkaline phosphatase (sBAP) were assessed for evaluation of bone resorption and formation, respectively. Results. In 74.3% (55/74) of the patients, BMDs were significantly reduced at 16 weeks relative to baseline. The percent changes of BMD were 21.89% (95% confidence interval [CI], 22.67% to 21.11%: p
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Nakamura, M., Ishiguro, A., Muranaka, T., Fukushima, H., Yuki, S., Ono, K., … Komatsu, Y. (2017). A Prospective Observational Study on Effect of Short-Term Periodic Steroid Premedication on Bone Metabolism in Gastrointestinal Cancer (ESPRESSO-01). The Oncologist, 22(5), 592–600. https://doi.org/10.1634/theoncologist.2016-0308
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