Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

Abstract

Here we describe the use of a new open-source software package and a Raspberry Pi® computer for the simultaneous control of multiple flow chemistry devices and its application to a machine-assisted, multi-step flow preparation of pyrazine-2-carboxamide - a component of Rifater®, used in the treatment of tuberculosis - and its reduced derivative piperazine-2- carboxamide. © 2014 Ingham et al; licensee Beilstein-Institut.