Chromanones from Lentinus crinitus (Basidiomycetes)

Abstract

The fungus Lentinus crinitus DR-5 (Basidiomycotina) produces in submerse culture the new natural products 2.2-dimethyl-6-methoxy-4-chromanone 1, its alcohol 3 and (S)-2,2-di-methyl-3-hydroxy-6-methoxy-4-chromanone 2. Beside these merohemiterpenes the antibiotically active hirsutane sesquiterpenes 5–8 were isolated. The formation of these metabolites displayed strong dependence from the carbon source in the medium. While lactose favoured the formation of the antibiotic sesquiterpene ketones 5 and 6, they were suppressed with mannose where the hemiterpenes 1 and 4 and the hirsutane-diol 8 were the dominating me-tabolites. © 1995, Verlag der Zeitschrift für Naturforschung. All rights reserved.