Focus on the Use of Resveratrol in Bladder Cancer

11Citations
Citations of this article
15Readers
Mendeley users who have this article in their library.

Abstract

Bladder cancer is the most common tumor of the urinary system, with a high incidence in the male population. Surgery and intravesical instillations can eradicate it, although recurrences are very common, with possible progression. For this reason, adjuvant therapy should be considered in all patients. Resveratrol displays a biphasic dose response both in vitro and in vivo (intravesical application) with an antiproliferative effect at high concentrations and antiangiogenic action in vivo (intraperitoneal application) at a low concentration, suggesting a potential role for it in clinical management as an adjuvant to conventional therapy. In this review, we examine the standard therapeutical approach to bladder cancer and the preclinical studies that have investigated resveratrol in xenotransplantation models of bladder cancer. Molecular signals are also discussed, with a particular focus on the STAT3 pathway and angiogenic growth factor modulation.

References Powered by Scopus

Resveratrol improves health and survival of mice on a high-calorie diet

3887Citations
N/AReaders
Get full text

Therapeutic potential of resveratrol: The in vivo evidence

3531Citations
N/AReaders
Get full text

AMPK regulates energy expenditure by modulating NAD + metabolism and SIRT1 activity

2735Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer

15Citations
N/AReaders
Get full text

Winemaking: “With One Stone, Two Birds”? A Holistic Review of the Bio-Functional Compounds, Applications and Health Benefits of Wine and Wineries’ By-Products

14Citations
N/AReaders
Get full text

Bioactive compounds from nature: Antioxidants targeting cellular transformation in response to epigenetic perturbations induced by oxidative stress

7Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Zucchi, A., Claps, F., Pastore, A. L., Perotti, A., Biagini, A., Sallicandro, L., … Fioretti, B. (2023, March 1). Focus on the Use of Resveratrol in Bladder Cancer. International Journal of Molecular Sciences. Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/ijms24054562

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 4

80%

Researcher 1

20%

Readers' Discipline

Tooltip

Pharmacology, Toxicology and Pharmaceut... 3

60%

Medicine and Dentistry 1

20%

Biochemistry, Genetics and Molecular Bi... 1

20%

Article Metrics

Tooltip
Mentions
Blog Mentions: 1
News Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free