The feasibility and benefits of using high-strength concrete for construction purposes in earthquake prone areas

Abstract

Transdermal delivery system bypass the hepatic first pass metabolism and avoid drug degradation due to gastrointestinal pH, enzymes etc., minimize plasma level fluctuations and extend the drug activity besides improving patient compliance. Transdermal films of metoprolol tartarate were prepared using polymers such as ethyl cellulose, poly vinyl alcohol, eudragit RL100, eudragit L100. Di-n-butylphlthalate was used as plasticizer. The study was undertaken to report the film forming properties of polymers used and in vitro drug release from the prepared monolithic matrices. Effect of drug loading on the drug release rate was also studied. The transdermal films were prepared using solvent casting method. These films were evaluated for Thickness, Percent moisture loss, Percent moisture absorption, Drug content, Weight variation and INTRODUCTION In recent years, considerable attention has been focused on the development of new drug delivery systems. Transdermal drug delivery system has been in existence for a long time. In past, the most commonly applied systems were topically applied creams and ointments for dermatological disorders. Drugs administered in the form of tablets, capsules, injectables and ointment etc., usually produce wide ranging fluctuation in drug concentrations in the blood stream and tissues and factors such as repetitive dosing and unpredictable absorption send lead to the concept of controlled drug delivery system or therapeutic system. Transdermal systems provide drug systemically at a predictable rate and maintain the rate for extended periods of time thus eliminating numerous problems associated with oral products such as unpredictable or reduced bioavailability, enhanced first patches across the freshly excised rat skin. MATERIALS AND METHODS Metoprolol tartarate was obtained as the gift sample from the Madras Pharmaceuticals Ltd, Chennai. Ethyl Cellulose, JPRHC Volume 2 folding endurance. In-vitro drug release kinetics was studied using Franz-diffusion cell. Drug release followed zero order kinetics. Drug loading at different concentrations found to have less effect on the film forming properties of the constituent polymers. Results have shown enhanced flux per unit time across rat skin. In conclusion combination of ethyl cellulose, poly vinyl alcohol, eudragit RL100, eudragit L100 and Di-n- butylphlthalate can potentially be optimized to develop an effective transdermal drug delivery system for metoprolol tartarate. Key words: Metoprolol Tartarate, Transdermal Delivery system, Eudragit RL 100, Eudragit L 100. pass