Association between serum soluble corin and hyperglycaemia: A cross-sectional study among Chinese adults

Abstract

Objectives: Decreased natriuretic peptides are risk factors for diabetes. As a physiological activator of natriuretic peptides, corin may play a role in glucose metabolism. Here, we aimed to test the hypothesis in a general population of China. Design: Cross-sectional study. Setting: A population study in Suzhou, China. Participants: A total of 2498 participants aged above 30 years were included in the study. Outcome measures: The association between serum soluble corin and hyperglycaemia was examined in men and women, using non-conditional logistic regression models, respectively. Results: Serum soluble corin, in men and women, was significantly higher in participants with hyperglycaemia than in those without (all p≤0.001). OR of hyperglycaemia positively and significantly increased with serum soluble corin quartiles, in men (p for trend ≤0.001) and in women (p for trend=0.050), even after multivariate adjustment. Participants with a serum soluble corin, in men (OR=1.66, 95% CI 1.24 to 2.23) and women (OR=1.27, 95% CI 1.00 to 1.61), over the median level, were more likely to have hyperglycaemia compared with the remaining participants, after controlling for confounding factors. Conclusions: Hyperglycaemia was significantly and positively associated with increased serum soluble corin in men and women. Our findings suggest that serum soluble corin may be a risk factor or a biomarker of hyperglycaemia.