Topical cyclosporin A in the management of vernal keratoconjunctivitis

Abstract

Purpose: To study the efficacy of topical cyclosporin A in children with vernal keratoconjunctivitis in a prospective randomised double-masked trial. Methods: Twenty-four children between 5 and 16 years of age were randomly treated with cyclosporin A (CsA) and placebo (vehicle) and followed up for 4 months. Results: Of the 12 patients given CsA, 11 showed symptomatic improvement by 7 days of starting treatment whereas only 3 patients in the placebo group showed mild symptomatic improvement. Conclusions: Topical cyclosporin is a safe and effective treatment in vernal keratoconjunctivitis.