Administration of endothelial progenitor cells (EPC) represents a promising option to regenerate the heart after myocardial infarction, but is limited because of low recruitment and engraftment in the myocardium. Mobilization and migration of EPC are mainly controlled by stromal cell-derived factor 1α (SDF-1α) and its receptor CXCR4. We hypothesized that adenosine, a cardioprotective molecule, may improve the recruitment of EPC to the heart.
Rolland-Turner, M., Goretti, E., Bousquenaud, M., Léonard, F., Nicolas, C., Zhang, L., … Wagner, D. (2013). Adenosine Stimulates the Migration of Human Endothelial Progenitor Cells. Role ofCXCR4 and MicroRNA-150. PLoS ONE, 8(1). https://doi.org/10.1371/journal.pone.0054135