Certain virus receptors are sequestered on the basolateral surface of polarized epithelial cells. A recent study has shown how adenovirus - and perhaps other viruses - are able to overcome this physical barrier.
Goosney, D. L., & Nemerow, G. R. (2003). Adenovirus infection: Taking the back roads to viral entry. Current Biology. Cell Press. https://doi.org/10.1016/S0960-9822(03)00037-X