Stem cells therapy for regenerative medicine: Principles of present and future practice

Abstract

The\rcharacterization and isolation of various stem cell populations, from embryonic\rto tissue-derived stem cells and induced pluripotent stem cells (iPSCs), have\rled to a rapid growth in the field of stem cell research and its potentially\rclinical application in the field of regenerative medicine and tissue repair.\rStem cell therapy has recently progressed from the preclinical to the early\rclinical trial arena for a variety of diseases states, although further\rknowledge on action mechanisms, long-term safety issues, and standardization\rand characterization of the therapeutic cell products remains to be thoroughly\relucidated. In this paper we summarize the current state of the art of basic\rand clinical research that were highlighted at the 2012 meeting of the Spanish\rCell Therapy Network. This includes the current research involving in genomic\rand transcriptomic characterization of selected stem cell populations, studies\rof the role of resident and transplanted\rstem cells during tissue regeneration and their mechanism of action,\rimproved new strategies of tissue engineering, transplantation of mesenchymal\rstem cells (MSCs) in different animal models of disease, disease correction by\riPSCs, and preliminary results of cell therapy in human clinical trials.