Purpose . We recently reported an association of adult BMI change with colon cancer risk. Here, we sought to further explore this association with respect to postmenopausal HRT use in a larger study population. Methods . We included 1,457 postmenopausal women participating in an ongoing population-based case-control study of colon cancer. Results . We confirmed a previously reported association of adulthood weight gain and increased risk of colon cancer: compared to those with <5 kg/m 2 change of BMI, women who reported moderate (5–10 kg/m 2 ) and large (>10 kg/m 2 ) BMI changes since their 20s had OR estimates of 1.54 (95% CI = 1.09–2.19) and 1.45 (95% CI = 0.90–2.33), respectively ( P for trend = 0.05). Stratified analyses showed that this association was limited to HRT nonusers: ORs were 1.77 (95% CI = 1.02–3.05) and 2.21 (95% CI = 1.09–4.45), respectively ( P for trend = 0.03), for BMI changes occurring between the 20s decade and time of recruitment among non-users. Similar associations were observed for BMI changes since the 30s decade. There was no association among HRT users. Conclusion . Our results suggest early adulthood weight gain increases colon cancer risk in postmenopausal women who do not use HRT.
Blake-Gumbs, L., Chen, Z., Thompson, C. L., Berger, N. A., Tucker, T. C., & Li, L. (2012). Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women. Journal of Obesity, 2012, 1–8. https://doi.org/10.1155/2012/857510