Advanced photonic biosensors for point-of-care diagnostics

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Abstract

The application of portable, easy-to-use and highly sensitive biosensor devices for real-time diagnosis could offer significant advantages over current analytical methods. Silicon photonic biosensors based on evanescent wave detection have revealed themselves as the most promise candidates for achieving truly point-of-care devices. Advantages as miniaturization, extreme sensitivity, robustness, reliability, potential for multiplexing and mass production at low cost can be offered. We present our work towards the assembly of a point-of-care device by using integrated silicon interferometers sensors, polymer microfluidics and diffractive grating couplers for light in-coupling. The micro/nanointerferometric devices have shown sensitivity close to 10 -7 in refractive index units, which means an ability to discern, in a label-free scheme, concentrations of biological molecules at pM level. © 2011 Published by Elsevier Ltd.

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González-Guerrero, A. B., Dante, S., Duval, D., Osmond, J., & Lechuga, L. M. (2011). Advanced photonic biosensors for point-of-care diagnostics. In Procedia Engineering (Vol. 25, pp. 71–75). https://doi.org/10.1016/j.proeng.2011.12.018

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