Advances in the understanding of protein-protein interactions in drug metabolizing enzymes through the use of biophysical techniques

6Citations
Citations of this article
22Readers
Mendeley users who have this article in their library.

Abstract

In recent years, a growing appreciation has developed for the importance of protein-protein interactions to modulate the function of drug metabolizing enzymes. Accompanied with this appreciation, new methods and technologies have been designed for analyzing protein-protein interactions both in vitro and in vivo. These technologies have been applied to several classes of drug metabolizing enzymes, including: cytochrome P450's (CYPs), monoamine oxidases (MAOs), UDP-glucuronosyltransferases (UGTs), glutathione S-transferases (GSTs), and sulfotransferases (SULTs). In this review, we offer a brief description and assessment of the impact of many of these technologies to the study of protein-protein interactions in drug disposition. The still expanding list of these techniques and assays has the potential to revolutionize our understanding of how these enzymes carry out their important functions in vivo.

Cite

CITATION STYLE

APA

Lampe, J. N. (2017, August 8). Advances in the understanding of protein-protein interactions in drug metabolizing enzymes through the use of biophysical techniques. Frontiers in Pharmacology. Frontiers Media S.A. https://doi.org/10.3389/fphar.2017.00521

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free